Myogenic defect in muscular dystrophy of the chicken☆
[摘要] Inheritedmusculardystrophyofthechickenisthoughttoarisefromabnormaldevelopmentoftrophicregulationofskeletalmusclesbytheirinnervatingnerves.Todeterminewhetherexpressionofmusculardystrophyinthechickenisapropertyofthenervesorofthemuscles,winglimbbudsweretransplantedbetweennormalanddystrophicchickembryosat312daysofincubation(stage19–20).Musclesofdonorlimbsinnervatedbynervesofthehostswerecomparedtocontralateralunoperatedhostlimbmusclesinchicksfrom6to25weeksafterhatching.Expressionofnormalordystrophicphenotypewasdeterminedbyexaminationoffivedifferentpropertieswhicharealteredindystrophicchickmuscle:electromyographicevidenceofmyotonia;fiberdiameter;acetylcholinesteraseactivity,localization,andisozymes;lacticdehydrogenaseactivity;andsuccinicdehydrogenaseactivity.Geneticallynormalmuscleinnervatedbynervesofnormalordystrophichostswasphenotypicallynormalwhilegeneticallydystrophicmuscleinnervatedbynormalnerveswasphenotypicallydystrophic.Theresultssuggestthatinheritedmusculardystrophyofthechickenarisesfromadefectofmuscleratherthanfromalesioninthenervesthemselves.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
