A genetic melanotic neoplasm of Drosophila melanogaster☆
[摘要] Tumlisasex-linkedrecessivelethalmutation.Themajorpathologicalconsequenceofthismutationishypertrophyofthelarvallymphglandfollowedbytheencapsulationoftheanteriormidgut,i.e.,theformationofmelanoticpseudotumors.InjectionoftheTumllarvallymphglandintoadultfemalehostsresultsinseveremelanization,growthoftheinjectedtissue,andprematuredeathofthehostanimals.ThetissuerecoveredfromahostinjectedwithTumllarvallymphglandsgrowsinsubsequenthosts,causestheprematuredeathofthosehosts,andmayormaynotgiverisetomelanizations.NoneoftheseeffectsisseeninhostsinjectedwithotherTumltissues,includingencapsulatedmidguttissueorinhostsinjectedwithwild-typelarvallymphglandtissue.UltrastructuralstudiesrevealthattheneoplastictissuederivedfromhostsinjectedwithTumllymphglandscontaincellswhichresembleDrosophilabloodcellsbothstructurallyandfunctionally.ThisevidencesuggeststhattheTumlmutationexpressesatruemelanoticneoplasminwhichneoplasticcellscapableofencapsulatingandmelanizingarecontinuouslyproduced.Thisisthefirstdemonstrationofamelanoticneoplasmassociatedwithamelanotictumormutation.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
