Cell differentiation in the absence of intracellular cyclic AMP pulses in Dictyostelium discoideum☆
[摘要] RepeatedadditionsofcyclicAMPtoamorphogeneticmutantofDictyosteliumdiscoideum,agip53,inducedcelldifferentiationtotheaggregationcompetentstateaspreviouslyreported[Darmon,Brachet,andPereiradaSilva(1975).Proc.Nat.Acad.Sci.USA72,3163–3166].CyclicAMPadditionselicitedtransientincreasesoftheintracellularcyclicGMPconcentrationbutnosignificantincreasesoftheintracellularcyclicAMPconcentration.TheseresultssuggestthattransientincreasesoftheintracellularcyclicAMPconcentrationarenotnecessaryforcelldifferentiation.Agip53seemstobeunabletorelaycyclicAMPsignals.Adefectinthereceptor-mediatedactivationofadenylatecyclasecouldbethebiochemicalbasisofthemutantphenotypeofagip53.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
