Modulation of myosin heavy chain turnover by spontaneous action potential generation in cultured dysgenic (mdg) muscle☆
[摘要] Musculardysgenesis(mdg)isanautosomalrecessivemutationinwhichskeletalmuscleexcitationandcontractionareuncoupled.Invitro,actionpotentialgenerationtriggersthemorphologicaldeteriorationofdysgenicmyotubes.Activedysgenicmuscleisvacuolatedandatrophied.Cellulardegenerationisaccompaniedbyadecreaseintheamountofmyosinheavychain(MHC)accumulatedinactivemdgmusclecomparedtothataccumulatedinquiescentmdgmuscle.AmarkedincreaseintherateofMHCdegradationprimarilyaccountsfortherelativelylowquantitiesofMHCincellsgeneratingactionpotentials.MHCsynthesisisonlyslightlyreducedinactivecells.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
