Reversible loss of acetylcholine receptor clusters at the developing rat neuromuscular junction☆
[摘要] Exposureofsternomastoidmusclesexcisedfrom16-dayembryonicratstomediumdepletedofCa2+orcontaininghighconcentrationsofKClleadstoextensivelossofaggregatesofacetylcholinereceptorsnewlyformedatthemotorendplateregion.UponrestorationofCa2+orremovalofexcessKCl,receptoraccumulationsreappearinthecentralregionsofaboutone-thirdofthemusclefibers.ThissusceptibilityofjunctionalAChRaggregateslastsonlyashortwhileduringdevelopmentoftheneuromuscularjunction.Bythetimeofbirth,endplatereceptoraggregateshavebecomeresistanttothesetreatments.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
