Mutations causing pattern deficiencies and duplications in the imaginal wing disk of Drosophila melanogaster☆
[摘要] PatterndeficienciesandduplicationsareproducedinderivativesoftheimaginalwingdiskbythemutationssdUCI,vg,tet,andwg1inDrosophilamelanogaster.InsdUCIandvgthemajorityofadultsshowasimplewingemarginationphenotype,butsomeofthemshowalmostcompletewingdeficiencyaccompaniedbyduplicationoftheremainingthoracicstructures.Intetandwg1thelatterclassofphenotypeisseeninsomeoftheanimals,buttheremainderarenormalandthesimpledeficiencyphenotypeisnotobserved.SerialsectionsofsdUCIandvgdisksrevealedextensivecelldeaththroughoutthethirdlarvalinstarinlocationscorrespondingtopresumptivewingblade.Asmallamountofscatteredcelldeathwasalsofoundinearlythirdinstarwild-typedisks,anditissuggestedthatthemutationssdUCIandvgaffectwingshapebyexaggeratingtheextentofnormalcelldeath.ThetypesofduplicationsseeninsdUCIandvgmutantadultsareconsistentwiththeknownregulativebehaviorofculturedfragmentsofimaginalwingdisks,andwethereforeproposethattheduplicationsareasecondaryresponsetodegenerationofalargepartofthedisk.Littlecelldeathwasseenintetandwg1duringthethirdlarvalinstar,sothesemutationsmaycausepatternduplicationbyadifferentmechanism.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
