Hyaluronate turnover during chondrogenesis in the developing chick limb and axial skeleton☆
[摘要] Hyaluronidaseactivityisfirstdetectedinlegandwingbudsandtheaxialtrunkregionofchickembryosattheonsetofcartilagedifferentiationandcontinuesduringsubsequentchondrogenesis.Incorporationofisotopicprecursorsintohyaluronateisdemonstratedinearlystagesofdevelopmentofbothlimbbudandaxialskeleton.Theratiosofincorporationofacetate-3Hintohyaluronateandchondroitinsulfateinbothregionsishigherpriortotheappearanceofcartilagethansubsequentlyandisgreateratallthestagesofaxialchondrogenesisstudiedthanatcorrespondingstagesinthelimbbud.Ahypothesisisfurtherdiscussedinwhichhyaluronateproductionaccompaniesmesenchymalcellmovementsanditsremovalisnecessaryfordifferentiationofthesecells.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
