The postnatal accumulation of S-100 protein in mouse central nervous system. Modulation of protein synthesis and degradation☆
[摘要] AstudywasmadeoftheratesofsynthesisanddegradationoftheS-100proteinduringthepostnataldevelopmentofthemousecentralnervoussystem.From3to15daystheS-100concentrationremainsconstant.From16to21daysS-100accumulates,risingfromabout4μgperbraintoalevelofapproximately16μgperbrain.From21daysto10moofage,theS-100concentrationremainsconstant.Thezero-orderrateconstantofsynthesisandthefirst-orderrateconstantfordegradationweredeterminedduringtheseperiodsbymeansofisotopeincorporationstudies.Initiationofaccumulationisaccompaniedbyanincreaseinbothratesofsynthesisanddegradation.DuringaccumulationofS-100therateofdegradationremainsconstantwhiletherateofsynthesiscontinuallyincreases.Cessationofaccumulationiscausedbyadecreaseinbothratesofsynthesisanddegradation.Thereforethecontroloftheaccumulationofthisproteinduringmousecentralnervoussystemdevelopmentisaresultofmodulationofbothratesofsynthesisanddegradation.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
