Lysine-rich histone phosphorylation and hyperplasia in the developing rat☆
[摘要] Electrophoreticcomparisonsofhistonesfromdevelopingratliverfromthe15-dayfetustotheagedadulthaverevealeddifferencesonlyinthelysine-richhistones.Thelysine-richhistonesfromrapidlydividingfetalcellsareextensivelyphosphorylated(∼80%)whiletheF1fromnondividingadultlivercellscontainsnodetectablephosphorylation.BetweenthesetwoextremepointstheextentofF1phosphorylationdeclinesastherateofcellreplicationdecreases.WeproposethatnotonlyistheextentofF1phosphorylationcorrelatedwiththeoverallrateofcelldivision,butthatitmaydependuponthefractionofcellsproceedingthroughtheSphase(DNAsynthesis)atagiventime.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
