Human teratogenesis: In vitro studies on thalidomide-inhibited chondrogenesis☆
[摘要] Chondrogenictissuesfrom5to8.5-wk-oldhumanembryoswereexposedinvitrototheteratogenicdrugthalidomide.Theresultssuggestthatamajorsiteofactionofthalidomideisupontissueassociatedwiththemesonephros.Humanmesonephrosfromembryos5–7wkoldcansynthesizeinvitroanextracellularmatrixwhichhasallthecharacteristics,histologicalandbiochemical,ofcartilage.Theabilityofembryonicmesonephrostoformcartilageinvitroisassociated,inanasyetunknownmanner,withinvitrolimbchondrogenesis.Itisproposedthatmesonephricmesenchymeataspecificstageofdevelopmenthasapositiveinfluenceuponlimbchondrogenesis.Thalidomideinhibitsthisinteraction,andinhibitschondrogenesis.Nootherchondrogenictissue,evenisolatedlimbtissue,wasfoundtobeinhibitedbythalidomidetreatment.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
