Uncoupling of gonial and spermatocyte stages by means of conditional lethal mutations in Drosophila melanogaster
[摘要] TwoconditionallethalswhichchangethedevelopmentalfateofgonialcellsinmaleDrosophilamelanogasterhavebeenisolated.1(1)63arrestsmitosesingonialcysts(andothertissues)beforethefourdivisioncycleshavebeencompleted,butallowsmeioticdivisionsandnormalspermatiddifferentiationtoproceed.Gonialdivisionsintestesof1(1)55,ontheotherhand,continuewellaftertheusualfourdivisions,andasaresult,cystswithhundredsofcells,manyofwhichlaterdegenerate,areformed.Itissuggestedthatfourgonialdivisionsarenotaprerequisitegeneticallyandmetabolicallyforspermatocytedifferentiationandthattheactivationofthespermatocyteprogramisnotpredeterminedbutratherrequiresthearrestofthegonialprogram.Otherimplicationsofthefindingsforourunderstandingofthegeneticcontrolofspermiogenesisarebrieflydiscussed.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
