Mutants of the bithorax complex and determinative states in the thorax of Drosophila melanogaster☆
[摘要] Homoeoticmutationsofthebithoraxcomplexcausesegmentaltransformations.Thegenesinwhichthesemutationsoccuraregoodcandidatesforgenesthatareinvolvedindetermination.Thedeterminationsysteminimaginaldiscsmusthaveatleasttwofunctions.Oneisacellheredityfunctionthatisresponsibleformaintainingthedeterminedstateduringgrowthanddevelopment.Asecondistheexpressionofthedeterminedstate(e.g.,differentimaginaldiscshavedifferentmorphologies).Thehomoeoticmutationsofthebithoraxcomplexcouldbeaffectingeitherofthesetwofunctions.Ihavefoundthatwhenposteriorhalteredisccells,thataretransformedbythemutationpostbithoraxsothattheyformwingcuticleinsitu,regenerateanteriorstructures,thesestructuresareanteriorwing.Thisisthesameresultasthatseenwhenwild-typeposterior-wingdisccellsregenerateanteriorstructures.Ontheotherhand,whenanteriorhalteredisccellstransformedbythemutationbithorax3,sothattheyproducewingcuticleinsitu,regenerate,theyproduceposteriorhalterestructures.Thisisunlikewild-typeanterior-wingdisccells,whichregenerateposterior-wingstructures.Fromtheseresults,Iconcludethatbithorax3affectstheexpressionofthedeterminedstateandpostbithoraxaffectsthecellheredityofdetermination.
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[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
