Cell cycling and DNA replication in a mutant blocked in cell division in the nematode Caenorhabditis elegans
[摘要] ThepostembryonicdevelopmentofthenematodeCaenorhabditiseleganshasbeendescribedatthelevelofindividualcelllineages.Amutantofpostembryonicdevelopment,lin-5II,causesafailureofpostembryonicnuclearandcelldivisions.Mitosisinlivinganimalsisseenbylightmicroscopytoproceedthroughprophaseandnuclearenvelopebreakdown,butanabnormal-lookingmetaphaseplateformsinthemutant,afterwhichtheinterphasenuclearmorphologyreappearsuntilthenextattemptedroundofdivision.Theprecursorcellswhichgiverisetotheventralnervecordhavebeenstudiedinlin-5.Inthewildtypethesecellsdivideasymmetricallytogivesixdescendants(onehypodermalcellandfiveneurons).InthemutanttheseprecursorsaccumulateapproximatelysixtimesthediploidquantityofDNAwithinasinglenucleus,whileattemptingmitosisuptothreetimes.Thesepolyploidcellsdisplaycharacteristicsofthecellstheywouldhaveproducedordinarily.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
