The control of avian cephalic neural crest cytodifferentiation: II. Neural tissues
[摘要] Aseriesofneuralcresttransplantationshasbeenperformedto(1)analyzewhetheravianpremigratorycranialneuralcrestcellsarepluripotentialorrestrictedtospecificdevelopmentalpathwaysand(2)examinetheabilityoftrunkneuralcrestcellstodevelopinanenvironmentusuallyoccupiedbycranialcrestcells.Quailembryos,thecellsofwhichhaveauniquenuclearmarker,wereusedasdonorsandchickembryosashosts.Hindbraincrestcellsgraftedintheplaceofdiencephaliccrestcellsfailedtoformneuronsinallbutonecase,inwhichasmallectopicganglionwasfound.Inthereciprocaltransplants,neuralcrestcellsemigratingfromasegmentofforebraincresttissuegraftedintheplaceofmetencephaliccrestcellsproducedtrigeminalandciliarygangliawhichwerecompletelynormal.Thus,crestcellswhichnormallyneverformganglionicneuronswilldosoifplacedinasuitableneurogenicenvironment.Theseresultsprovethatpremigratoryaviancranialcrestcellsarenotrestrictedtospecificdevelopmentalpathways,butareinitiallypluripotential.Trunkcrestcellsgraftedintheplaceofmetencephaliccrestcellsformneuronalgangliaalongtheproximaltrigeminalmotorrootsbutdonotformnormaltrigeminalganglia.Theserootgangliadonotdisplaynormalperipheralprojections,andplacodecells,anormalcomponentofthetrigeminalganglion,formgangliainectopiclocations.Thus,whiletrunkcrestcellsrespondtothemetencephalicenvironmentandformneurons,theirresponseisdifferentfromthatofcranialcrestcellsinthesamelocation.Whetherthisisduetodifferencesindevelopmentalpotentialorininitialpopulationsizeisnotknown.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
