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Further studies on the secondary antibody-forming potential of juvenile, young adult, adult, and aged mice☆
[摘要] Thesecondaryantibody-formingpotential(SAFP)perspleenwithinanyagegroupofmice,exceptfortheveryold,wasgreateramongdonorswithpersistingprimaryserumantibodytiterthanamongthosewithout,butthisrelationshipwasnotquantitative,norwasitapparentbetweendonorsofdifferentagegroups.TheestimatedrelativenumberofprogenitorcellsinthespleenwasdirectlyrelatedtotheSAFPofthespleen.AmongveryoldmicetheSAFPpermousewasaslowastheprimaryantibody-formingpotential(PAFP)permouse,buttheSAFPperspleenwasgreaterthanthePAFPperspleen.ThePAFPofsmallspleenswasgreaterthanthatoflargespleens.Decreaseincapacityofveryoldmicetosynthesizemercaptoethanol-resistantantibodywasmorepronouncedthandecreaseincapacitytosynthesizemercaptoethanol-sensitiveantibody.Studiesontheeffectofprimingjuvenile,youngadult,andadultmicewithanadequatedoseofantigenrevealedthatthemaximumlevelofSAFPisdirectlyrelatedtothelevelofPAFPatthetimeofpriming.Theappearanceofasignificantnumberofprimedprogenitorcellsafterprimaryantigeninjectiondoesnotprecedetheappearanceoffunctionalantibody-formingcells.Thesignificanceoftheseresultstoourunderstandingofthecytokineticsofantibodyresponseandagingofindividualsisemphasized.
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[效力级别]  [学科分类] 生物科学(综合)
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