Immunological tolerance induced in rabbits toward saline homogenates of chicken spleen and liver
[摘要] 1.1.Newbornrabbitsweregivenseventoninedailyintraperitonealinjectionsofsalinehomogenatesofadultchickenspleenorlivertoatotaldoseof10,25,50,or100mgofprotein.2.2.Rabbitsinjectedwith25–100mgofspleenatbirthshowanaveragefour-tofivefoldreductionoftiterascomparedtocontrolswhenchallengedattheageof11weeks.Thosegiven10mgaverage1–2tubeslowerthanthecontrols.3.3.Rabbitsinjectedneonatallywith10mgoflivershowvirtuallynotoleranceat11weeksofage;25mgeffectsa2-tubereductionintiter,with100mgproducingathreefolddrop.4.4.Animalstreatedidenticallyatbirthbutnotchallengeduntilheageof20weeksalsoarepartiallytolerant,butnotasmuchasat11weeks.5.5.Regardlessofprecipitintiter,theseraofnearlyallexperimentallytreatedrabbitsgivemorebandsbyagar-diffusiontechniquesthantheseraofcontrols.Thisfindingisinterpretedasaresponsebytheserabbitstowardminorantigeniccomponentsoftheextractsfollowingsuppressionoftheircapacitytorespondtowardthefewmajorcomponents.6.6.Thepotentialvalueofsuchatechniqueinthepreparationoforgan-specificantiseraisdiscussed.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
