Embryonic potency of embryoid bodies derived from a transplantable testicular teratoma of the mouse☆
[摘要] Testicularteratomasoccurrelativelyfrequentlyininbredstrain129mice.Occasionallytheygrowprogressivelyandsurviveserialtransplantationindefinitely.Onesuchtumorhasbeenmaintainedforapproximatelysixyears,anditstillretainsitshighlypleomorphicnature.Whenestablishedasanascitictumor,thisteratomaiscapableofproducingthousandsoffree-floatingformationsthatresemble5-and6-daymouseembryos.Theaimofthisinvestigationwastotestthehistogeneticcapacitiesoftheseembryoidbodies.Singleembryoidbodiesweretransplantedintotheanteriorchamberoftheeyesofmaturestrain129mice.Growthsresultingfromtheseintraoculargraftswereexaminedhistologicallyandsomewereretransplantedsubcutaneouslytoformsolidtumorsublines.Boththeintraocularandsubcutaneousgraftscontainedmanytypesoftissues,includingavarietyofepithelia;neuraltissue;cartilagewithperipheralossification;smooth,cardiac,andvoluntarymuscle;trophoblasticgiantcells;layersofectodermandendoderm;andundifferentiatedembryonalcells.Itisconcludedthattheembryoidbodiesderivedfromthetesticularteratomasofstrain129micehavesimilaritiesinembryonicpotencyaswellasinmorphologytonormalmouseembryos.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
