Cytodifferentiation of the acinar cells of the rat submandibular gland☆
[摘要] Thepresentstudyexaminesthecytodifferentiationoftheacinarexocrinecellsoftheratsubmandibulargland(SMG)attheultrastructurallevel.Submandibularglandsfromratsat14daysofgestationthrough12weekspostpartumwereexamined.TheacinarcellsoftheSMGbegintodevelopat15–16daysofgestationandarenotfullydifferentiateduntil3–4weeksafterbirth.TheearliestcellsshowmultipleGolgizonesandafewstrandsofwidelydilatedroughendoplasmicreticulum(rer).Subsequently,thecellsshowanorderlysequenceoforganellechangesandrearrangementwhichleadstofullydifferentiatedexocrinecells.Aseriesoffivemorphologicallydistinctsecretorygranulesisobservedduringdifferentiationandthesegranulesserveasmarkersofthefunctionalmaturityofthecells.Attentionisgiveninthisstudytothedevelopmentoftheapical-basalpolarityoffunctionalorganellestypicallyseeninexocrinecellsanditsrelationshiptosecretorygranuleproduction.Thefindingsofthecurrentstudyarecomparedwithsimilarreportsintheliteratureonthedevelopingpancreasandparotidglandoftherat.Itisconcludedthatdifferentdevelopmentalpathwaysarefollowedtoattainasimilarfunctionalcapacityinthethreeorgans.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
