Development of cholinergic innervation in the hippocampal formation of the rat: II. Quantitative changes in choline acetyltransferase and acetylcholinesterase activities☆
[摘要] Thepostnataldevelopmentofcholineacetyltransferase(ChAc)andacetylcholinesterase(AChE)activitieshasbeenstudiedinthehippocampalregionoftheratbrainandindiscretelayersofthedentategyrus.Becausethehippocampalregionreceivesitscholinergicinnervationpredominantlyfromasinglesource,thesedatacouldberelatedtodevelopmentwithinadefinedcentralcholinergicprojection.ThespecificactivityofChAcislowanduniforminalllayersofthedentategyrusat11daysofage.Itattainsadultvalueswithinabriefperiodaround16–17days.Weinterpretthisfindingasacorrelateofcholinergicsynaptogenesis.ItisnotaccompaniedbyanincreaseofsimilarmagnitudeinAChEactivity,whichattainsmaturevalueslaterandatamoregradualrate.ThesefindingsareintegratedwithAChEhistochemistrytoformulateadevelopmentalsequenceinthecholinergicinnervationofthedentategyrus.Less-detaileddataondevelopmentofChAcandAChEactivitiesinthehippocampalregionasawholesuggestasimilarsequenceindivisionsotherthanthedentategyrus.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
