Contribution of BDNF-Mediated Inhibition in Patterning Avian Skin Innervation
[摘要] Multiplefactorsareinvolvedinthedevelopmentandregulationofsensoryinnervationinskin.Thefindingswereportheresuggestthatbrain-derivedneurotrophicfactor(BDNF)-mediatedinhibitionmayplayanimportantroleindeterminingthepatternofsensoryinnervationinavianskin.Inbirds,cutaneousinnervationisrestrictedtodermis,whereaxonsformaringofinnervationaroundthebaseofeachfeather.HereweshowthatbothBDNFmessageandproteinaremoreabundantinavianepidermisthandermiswheninnervationisbeingestablished;theBDNFindermisislocalizedtofeatherbuds.Invitro,BDNFcausedgrowthconesofNGF-dependentdorsalrootganglionneuronstocollapse.Similarly,outgrowthofneuritestowardBDNF-secretingfibroblastswasinhibited.TheinhibitoryeffectsofBDNFappeartobemediatedbythelow-affinityp75neurotrophinreceptor,ratherthanatrkreceptor.Thus,thedistributionofBDNFinembryonicavianskinandtheinhibitoryeffectsofBDNFoncutaneousneuritesinvitrosuggestthatBDNFmaybeimportantinrestrictingaxonsfromenteringtheepidermisandthecoreoffeatherbudsduringdevelopmentinvivo.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] skin;development;chick;BDNF;sensory innervation;cutaneous;inhibition [时效性]
