pasilla, the Drosophila Homologue of the Human Nova-1 and Nova-2 Proteins, Is Required for Normal Secretion in the Salivary Gland
[摘要] FromascreenforgenesexpressedandrequiredintheDrosophilasalivarygland,weidentifiedpasilla(ps),whichencodesasetofproteinsmostsimilartohumanNova-1andNova-2.Nova-1andNova-2arenuclearRNA-bindingproteinsnormallyexpressedintheCNSwheretheydirectlyregulatesplicing.Inpatientssufferingfromparaneoplasticopsoclonusmyoclonusataxia(POMA),Nova-1andNova-2proteinsarepresentasauto-antigens.Consistentwitharoleinsplicing,PSislocalizedtonuclearpuncta.Thesalivaryglandsofpsmutantsinternalizenormallyandmaintainepithelialpolarity.However,themutantsalivaryglandsdevelopirregularitiesinoverallmorphologyandhavedefectsinapicalsecretion.ThesecretorydefectsinpsmutantsprovideapotentialmechanismforthelossofmotorfunctionobservedinPOMApatients.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] Drosophila;KH-domain;morphogenesis;Nova-1;Nova-2;POMA;RNA-binding protein;salivary gland;secretion;splicing [时效性]
