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Development of an open eyelid mutant in Mus musculus☆
[摘要] 1.1.Thedevelopmentandhistologyoftheeyeisdescribedforaninheritedconditiondesignatedasslitlidsinwhichtheeyelidsareeitherthinoropenatbirth.2.2.Almostinvariablythelenswasthefirstportionoftheeyeaffected.Theprimarydefectwasanabnormaldegreeofvacuolizationanditsearliestappearancewasat14–15daysofgestation.3.3.Atlaterages,usuallyafterbirth,corneasandretinasalsoshoweddefectsandthelensdefectsfrequentlyincreasedinseverity.Lenseswereextrudedinsomeanimals;corneaswerethickened,opaqueandcoveredbyscabs;neuralretinaswerefoldedandrosetted.4.4.Comparisonwithtwoothermutantswithopeneyelidsatbirthindicateddifferencesinorderandageofappearanceofthevariouseyeeffectsandsomedifferencesinhistology.5.5.Itissuggestedthatthelensdefectinmicewithslitlidsmaytriggerthesyndromebyaffectingthevitreoushumorandhenceintraocularpressure.
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[效力级别]  [学科分类] 生物科学(综合)
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