Development of an open eyelid mutant in Mus musculus☆
[摘要] 1.1.Thedevelopmentandhistologyoftheeyeisdescribedforaninheritedconditiondesignatedasslitlidsinwhichtheeyelidsareeitherthinoropenatbirth.2.2.Almostinvariablythelenswasthefirstportionoftheeyeaffected.Theprimarydefectwasanabnormaldegreeofvacuolizationanditsearliestappearancewasat14–15daysofgestation.3.3.Atlaterages,usuallyafterbirth,corneasandretinasalsoshoweddefectsandthelensdefectsfrequentlyincreasedinseverity.Lenseswereextrudedinsomeanimals;corneaswerethickened,opaqueandcoveredbyscabs;neuralretinaswerefoldedandrosetted.4.4.Comparisonwithtwoothermutantswithopeneyelidsatbirthindicateddifferencesinorderandageofappearanceofthevariouseyeeffectsandsomedifferencesinhistology.5.5.Itissuggestedthatthelensdefectinmicewithslitlidsmaytriggerthesyndromebyaffectingthevitreoushumorandhenceintraocularpressure.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
