Glycogenesis in the guinea pig liver during development☆
[摘要] Theincorporationof14C-labeledglucose,pyruvate,andfructoseintoglycogenwasmeasuredinahigh-potassiummediumusingslicesofguineapigliverfromanimalsofdifferentages.Theincorporationofallthreeprecursorswasfoundtobelowinfetallivereventowardtheendofgestationwhenchemicaldeterminationsofglycogenshowedarapidaccumulationofthissubstance.Itwassuggestedthatthepostnatalincreaseofglucoseincorporationintoglycogentogetherwiththeincreasedconcentrationdependencewasduetotheappearanceofthehigh-Kmglucokinaseactivity.Fructose1,6-diphosphataseactivityofguineapigliverwasfoundtobesubjecttoproteolyticactivationthroughoutdevelopment.Changesintheactivityofthisenzymewerenotconsideredtobeofsufficientmagnitudetoexplainthepostnatalincreaseoftheincorporationofpyruvateintoglycogen.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
