Refinement of wingless Expression by a Wingless- and Notch-Responsive Homeodomain Protein, Defective Proventriculus

[摘要] Patternformationduringanimaldevelopmentisofteninducedbyextracellularsignalingmolecules,knownasmorphogens,whicharesecretedfromlocalizedsources.DuringwingdevelopmentinDrosophila,Wingless(Wg)isactivatedbyNotchsignalingalongthedorsal–ventralboundaryofthewingimaginaldiscandactsasamorphogentoorganizegeneexpressionandcellgrowth.ExpressionofwgisrestrictedtoanarrowstripebyWgitself,repressingitsownexpressioninadjacentcells.Thisrefinementofwgexpressionisessentialforspecificationofthewingmargin.Here,weshowthatahomeodomainprotein,Defectiveproventriculus(Dve),mediatestherefinementofwgexpressioninboththewingdiscandembryonicproventriculus,wheredveexpressionrequiresWgsignaling.Ourresultsprovideevidenceforafeedbackmechanismthatestablishesthewg-expressingdomainthroughtheactionofaWg-inducedgeneproduct.

[学科分类] 生物科学（综合）

[关键词] Drosophila wing imaginal disc;Notch;wingless;defective proventriculus;morphogen;pattern formation