Assessment of the Effect of Albumin Compared with Placebo on Functional Outcome in Subjects’ Post Brain Infarct in the Middle Cerebral Artery Territory in Patients Referred to Golestan Hospital of Ahvaz

[摘要] BackgroundandObjective:Strokeisthethirdcommoncauseofmortalityandthemostcommoncauseofmorbidityinelderlypersons.Albuminisatreatmentindicatedforpost-strokerecovery.Theaimofthisstudywastoinvestigatetheeffectofalbuminonthefunctionaloutcomeattheendofthethirdmonthinpost-strokesubjects.SubjectsandMethods:Thisisadouble-blinded,placebocontrolled,randomizedstudyof139subjectsincludedwithin5hrofstrokeonset.Allsubjectsweregiveneitheralbumin(20%)orplacebo(isovolumicnormalsaline)withatadoseof1g/KgIVinfusionover2hr.BarthelindexscoreandmodifiedRankinscalewereusedforassessmentatbaselineandat3months.Results:Albuminadministrationhadsignificanteffectinreductionoflengthofhospitality(Plt;0.05).However,therewasnosignificantdifferenceinmortalityratebetweenalbuminandplacebogroup(Pgt;0.05).SubjectsinthetreatmentgroupshowedasignificantdifferenceintherankofMRS:61.6vs78.2intheplacebogroupandmeanchangeoftheBarthelIndex:38versus28,respectively.Thetimefromstrokeonsettoalbumintherapyinitiationiseffectiveinclinicalimprovementofpatients(Plt;0.05).Conclusion:Itseemsthatadministrationofalbuminhassignificanteffectinimprovingtheclinicalfunctionofthepatientsandreducesthelengthofhospitalization,especiallyinsmallerstrokesandwhentreatmentisinitiatedearly.

[学科分类] 基础医学