The Effect of Vaginal Administration Isosorbide Mononitrate on Cervical Ripening and Iduction of Labor In Postterm Pregnancy

[摘要] BackgroundandObjective:SeveralfindingshaveshownthatNitricoxidedonorscanbeeffectiveforcervicalripening.TheaimofthisstudywastodeterminewhetherIsosorbidemononitrate(IMN)administratedvaginallyiseffectiveforcervicalripeningandinductionoflaborinnulliparewomenat40–42weeksgestation.SubjectsandMethods:Adoubleblind,placebo–controlled,randomizedclinicaltrialwascarriedoutattheSinahospitalinAhvazin2010.Eightynulliparouswomenwithuncomplicatedpregnancy,Cephalicsingletonfetusat40–42weeksofgestationandBishopscore≤4wereallocatedrandomlytoreceiveeitherIsosorbidemononitrate(2×20mg)orplacebo(2tablets)vaginallyfortwodosesatleast24hoursbeforeinductionoflaborwithoxytocin.ModifiedBishopScoreafter24hours,inductiontoactivephaseintervalanddurationofactivephasewereevaluatedineachgroup.Thedatawereanalyzedusingt-test,chisquare,SurvivalAnalize(KaplanMayer)andRepeatedmeasureinSpssver16.0.P-valuelessthan0.05wereconsideredasstatisticallysignificant.Results:IntheIMNgroup,therewasasignificantincreaseinthemeanmodifiedBishopscore(p=0/008).Meandurationbetweeninductiontoactivephaseoflaborwasshorterintheinterventiongroupthanthecontrol(p=0/03).Meandurationofactivephasewasnotdifferentinthetwogroups(pgt;0/05).Nomaternalorfetalsideeffectswereregistered(pgt;0/05)expectheadacheincasegroup(plt;0/001).Conclusion:VaginaladministrationIsosorbidemononitrateisprobableeffectiveforcervicalripening.

[学科分类] 基础医学