Comparison of Clinical, Laboratory and Radiological Characteristics in Hospitalized Diabetic and Non Diabetic Patients with Community Acquired Pneumonia

[摘要] BackgroundandObjective:community-acquiredpneumonia(CAP)isalife-threateningdiseaseinpatientswithdiabetesmellitus(DM).DMisassociatedwithanincreasedsusceptibilitytoinfectionandincreasedmorbidityandmortality.Theaimofthepresentstudywastoprovideinformationonclinical,laboratoryandradiologicalcharacteristicsandtheoutcomeofCAPinpatientswithDM.SubjectsandMethods:Duringatwoyearsperiod(2009-2010),westudiedtheclinical,laboratoryandradiologicalcharacteristics,thespectrumofcausativeagentsandtheoutcomesof264casesofCAP.Dataderivedfrom42patientswithDMwereanalyzedandcomparedwithdataobtainedfromtheremainingCAPpatients.Results:PatientswithDMweresignificantlyolder(P=0.02)andweremorefrequentlyassociatedwithothercomorbidconditionssuchascardiacfailureandhypertension(Plt;0.0001).Fever(Plt;0.0001)anddyspnea(P=0.03)weremorefrequentinDMpatients.Lobarconsolidation,bilateralinfiltrationandpluraleffusionwerethemostcommonimagingfindingsinchestradiography.Pleuraleffusion(P=0.002)andlobarconsolidation((P=0.02)weremorefrequentlyfoundinDMpatients.Bycontrast,theincidenceofthemainetiologicagentssuchasS.pneumoniae(Plt;0.0001`)andK.pneumoniae(P=0.001)amongDMpatientsshowedsignificantdifferencesinrelationtotheremainingpatients.InthesubgroupofpatientswithDM,mortalitywassignificantlyhigherthanno-diabetics(P=0.03).Conclusions:InpatientswithCAP,DMisassociatedwithadifferentclinical,laboratoryandradiologicalcharacteristics,andwithhigherrateofcardiovascularcomplicationsuchascongestiveheartfailureandhypertension,increasingtherateofmortality

[学科分类] 基础医学