Camparision Results of Administration of Glucoseamine and Glucoseamine with Alendronate in Symptomatic Relieve of Knee DJD

[摘要] BackgroundandObjective:DegenerativeJointdisease(DJD)isthemostcommonjointdiseaseinhumanandthemostcauseofchronicdisabilityinagingpapulationindevelopedcountries.SeveralstudiesexplainthatglocosamineIsbetterthanplaseboanditsefficacyismoreincomparisonwithNSAIDinkneeosteoarthriticpatient.Alendronateisprescribedforosteoprothicpatients.Theaimofthisstudywastocomparetheefficacyofadminstrationofglocoseaminealoneandincombinationwithalendronateinosteoarthritisoftheknee.SubjectsandMethods:Atotalof130patientsofeithersexwithosteoarthritiswereincludedinthestudyandrandomisedtoreceiveglocoseaminealone(500mgTDS)andcombinationofGlocoseamine(500mgTDS)andalendronate(70mgweeky)for12weeks.Thepatientswereevaluatedat1;3;6and12weeksforefficacy.Results:Therewasnotstatisticalysignificantdecreaseinpainindex(pgt;0.05)butintotaltherapythemeanofpainisdecreased.Thestiffnesindexincombinationtherapywasdecreased(plt;0.05).Thefunctionofjointincombinationtherapywasimprovedafter12weeks.TheBMDafter12weekscombinationtherapywasimproved.Conclusion:Combinationtherapyofglocoseamineandalendronatewassignificantimprovementofstiffness,function,BMDofosteoarthritiscomparedwithglocoseaminealonebuttherewasnotstatisticallysignificantdecreasedinpainindex.Itcanbeconcludedthatthecombinationofglocoseaminewithalendronateprovidebetterandmorerapidimprovementinpatientswithosteoarthritis.

[学科分类] 基础医学