Is the Prevalence of Focal and Segmental Glomerulosclerosis Increasing in the Province Of Khuzestan?

[摘要] BackgroundObjective:Thereisevidencethatfocalsegmentalglomerulosclerosis(FSGS)hasbecomeanimportantcauseofadultprimarynephroticsyndrome(PNS)intheUSAandmanyothercountriesandtheaimofthisstudywastoevaluatethisissueintheprovinceofKhuzestan,Iran.SubjectsandMethods:InacrosssectionalandprospectivestudyfromJanuary1998toSeptember2012,allthepatientswithPNSwhoreferredtoImamKhomeinihospitalofAhwaz,Iranwereevaluated.Renalbiopsywasdonebynephrologistsandthebiopsysampleswereanalyzedbylightmicroscopy.Results:148patients(53maleand39female,meanage51±33years)wereincluded.Meanserumcreatinineandamedianrateofurinaryproteinexcretionwere1.39mg/dland6450mg/dayrespectively.Themostcommonhistologicalfindingwasfocalandsegmentalglomerularsclerosis(FSGS)49patients,33.10%,followedbymembranousglomerulonephritis(MGN)42patients,28.37%,minimalchangedisease(MCD)18patients,12.16%,membranoproliferativeglomerulonephritis(MPGN)13patients,8.78%,IgAnephropathy10patients,6.75%,focalandsegmentalglomerulonephritis(FSGN)6patients,4.05%,mesangialproliferativeglomerulonephritis5patients,3.37%anddiffuseproliferativeglomerulonephritis5patients3.37%.Conclusion:Consistentwithseveralothercountries,FSGSisthemostcommoncauseofadultprimarynephroticsyndromeinKhuzestanprovince,Iran.

[学科分类] 基础医学