The Relationship between Serum Cortisol and Vitamin C Levels with Obesity

[摘要] BackgroundandObjectives:Throughhyperactivationofhypothalamic-pituitary-adrenalaxisandsubsequentelevationofserumcortisollevels,chronicstressmightleadtostress-inducedhyperphagiaandobesity.TherearelessphysicalandmentalstresssignsinpeoplewithhighlevelofserumvitaminC.TheaimofthisstudywastoassesstherelationshipbetweenserumvitaminCandcortisolwithobesity.SubjectsandMethods:Inthiscase-controlstudy,140healthywomen(46obeseand94normalweight)17-44yearsold,wererecruitedusingconvenientrandomsamplingmethod.Controlswereold-matched.GeneralobesitywasdefinedasBMI≥30Kg/m2andcentralobesityasWC≥88cm.SerumvitaminCandcortisollevelsweremeasuredusingchemicalandELISAmethods,respectively.Sinceanxiety,depressionandeatingattitudemaybeassociatedwithoversecretionofcortisol,weconsideredthemasconfoundersinourstudy.Thedatawereanalyzedbyt-testandlogisticregressionusingSPSSsoftware.Results:TherewerenosignificantrelationshipbetweenserumvitaminClevelswithBMI(P=0.70).Afteradjustingforconfounders,womeninthehighesttitresofserumcortisollevelswerelesslikelytohavegeneral(OR=0.2,P=0.05)andcentralobesity(OR=0.2,P=0.02).Conclusion:Inthisstudy,therewereasignificantinverserelationshipbetweenserummorningcortisollevelswithcentralandgeneralobesity,whiletherewerenoassociationsbetweenserumvitaminClevelsandobesity.Tothebestofourknowledge,thistypeofstudyhasneverbeenconductedbeforeinIranianwomen;andmorestudiesarerequiredtodelineatethenatureoftheserelationships.

[学科分类] 基础医学