The Effect of Punica Granatum Flower Extract, on Blood Glucose, Insulin, Insulin Tolerance, Lipid Profile and Blood Pressure in High Sucrose Diet Rats

[摘要] BackgroundandObjective:Diabetesmellitusisacommonmetabolicdiseaseintheworld.TheextractofPunicagranatumflower(PGF)hasbeenusedintraditionalmedicinetodecreasebloodglucoseandlipid.Theaimofthisstudywastoinvestigatetheeffectofthisplantinhighsucrosedietrats.SubjectsandMethods:Inthisexperimentalstudy,30adultfemaleWistarratsweighing150-170(g)wereused.Afterinducedinsulinresistancebysucrose32%indrinkingwaterfor6weeks,theanimalswererandomlydividedinto5groups:sucroseinduced,aqueous(400mg/kg)andhydro-alcoholic(300and500mg/kg)extractofPGF.Control(normal)groupwasconsumedonlydrinkingwater(n=6).48hoursafterthelastinteraperitonealinjection(IP),bloodwascollectedfromheart,serumwasseparatedandbloodglucose,insulin,fastinginsulinresistanceindex(FIRI),lipidprofiles,hepaticenzymesandbloodpressureweredetermined.Results:Bloodpressure,insulin,glucoseandFIRIinsucrose-inducedgrouptreatedwithextractsofPGFweresignificantlyincreasedincomparisonwiththecontrolgroup.ExtractsofPGFdecreasedthelipidprofilesignificantly;however,somehepaticenzymeswereincreased.Conclusion:TheresultsofthisstudyShowedthatPGFextractscanincreasebloodpressure,glucose,insulinandFIRIincomparisonwithsucrosegroup.Thus,thePGFanimalsdisplayedcharacteristicstypicalofinsulinresistanceanditissuggestedthattheinvestigatorcoulddomoreresearchonthisplant.

[学科分类] 基础医学