Comparison of Oral Pantoprazole and Famotidine on Gastric Vol-ume and Ph in Elective Surgeries

[摘要] Objectives:Perianesthesiaaspirationisathreateningsideeffect,whoseseveritydependsonpHandvolumeofaspiratedgastricjuice.Becauseofthelossofconsciousnesswhileanesthesia,theprotectivereflexesdisappearandexposethepersonintheriskofaspiration.Pharmacologicalattemptshavebeenmadetoeliminatetheriskofpulmonaryaspiration.TheaimofthisstudywastocompareoralpantoprazoleandfamotidineongastricvolumeandpHinelectivesurgeries.Methods:Inadouble-blindrandomizedclinicaltrial,120candidatesofelectivesurgerywererandomizedinto3groups(controlorC,pantoprazoleorPandfamotidineorFgroups).ThepatientsingroupCØŒPandFweregivenplaceboØŒpantoprazole40mgandfamotidine40mgorallyat11pmanightbeforesurgeryrespectively.Afterinductionofanesthesia,gastriccontentswereaspiratedandanalyzedforthepHandvolume.Results:PHvalueswere2.87±0.92ingroupC,4.53±1.29ingroupPand3.79±1.97ingroupF.TherewasstatisticaldifferencebetweengroupsC,PandF(P<0.05).TheresultsshowedaconsiderabledecreaseinthegastricvolumeingroupsPandFcomparingtogroupC.(P<0.05).Conclusion:WeconcludedthatoralpantoprazoleiseffectiveinreducinggastricpHcomparingtofamotidineandplaceboØŒandfamotidineiseffectiveinreducinggastricvolumecomparingtopantoprazole.

[学科分类] 基础医学

[关键词] Gastric pH;Pantoprazole;Famotidine