Halothane Induced Hepatitis (CME).
[摘要] Abstract::Halothaneisahalogenatedinhalationanesthetic.Itsthreetraceelementsarefluoride,chlorideandbromide.Fluorideiswellknownbybiochemiststobeaninhibitorofenzymes.Fluorideformsastronghydrogenbondwiththeamidegroup,andthushasthepotentialtointerferewithfundamentallife-processesinvolvingtheshapeandfunctionofbothproteinsandnucleicacids.Patientswithhalothanehepatitisorseverehepaticdamageduetootherhalogenatedanestheticsproduceantibodiesagainstseverallivertrifluoroacetylatedmicrosomalproteins.OtherstudiessuggestthatmolecularmimicryofN6-trifluoroacetyl-L-lysinbylipoicacid,ortheimpairmentthereof,mightplayaroleinthesusceptibilityofindividualsforthedevelopmentofhalothanehepatitis.Thespectrumofdiseasediffersfromaminotransferaseelevationeitherwithoutsymptomsorwithmild,self-limitedsymptomstoseverehepatitisoracuteliverfailure.Moreinvestigationisneededtounderstandthemechanismsofhalothanehepatotoxicity.Theaimofourreportistoprevent,recognizeandmanagethecomplicationsofhepatitisassociatedwithhalothaneadministration.
[发布日期] [发布机构]
[效力级别] [学科分类] 基础医学
[关键词] Halothane;Hepatitis;Anesthetic cares [时效性]
