Glyceryl Trinitrate Versus Magnesium Sulfate in the Suppression of Preterm Labor.

[摘要] Introduction::Pretermbirths(before37completedweekgestation)accountforapproxi-mately5-10%ofbirthsandarethemajorcauseofperinatalmortalityinNorthAmericaandEurope.Thisislargelybecauseofalackofstandardtreatmentsforthisproblem,therefore,theaimofthisstudywastocompareglyceryltrinitratewithmagnesiumsulfatefortheirabilitytosuppresspretermlabor.MaterialandMethods::AclinicaltrialwasperformedattheAliEbneAbitalebHospital,intheZahedanUniversityofMedicalScience.Intotal,42womenwithpretermlaborandintactmembraneswithagestationalagebetween27and37weeksweredividedintotwogroupsatrandom.Patientsintheexperimentalgroupreceivedglyceryltrinitrate(5mgrtransdermalpatches/24hours)andinthecontrolgroup,magnesiumsulfate(atfirst4grinfusion:1gr/minandthen2gr/hour)wasuseduntilthesuppressionofpretermuterinecontractionswasobserved.Resultswereobtainedthroughobservationandinterviewforms,andtheresultingdatawasanalyzedusingchisquareandTtestsavailableintheSPSSstatisticalsoftware(P#60;0.05).Results::Meandurationofpregnancyprolongationwas14.87daysinthecasegroup(min:11max:59.38SD:14.28)and13.44daysinthecontrolgroup(min:26max:36.63SD:14.77).Therewasnosignificantdifferenceintheprolongationofpregnancybetweenglyceryltrinitrateandmagnesiumsulfate(P#60;0.05).Conclusion::Glyceryltrinitrateisasuitablesubstituteformagnesiumsulfateinthesuppres-sionofpretermlabor.

[学科分类] 基础医学

[关键词] Glyceryl Trinitrate;Magnesium Sulfate;Preterm Labor