The Effect of Beclomethasone Nasal Spray on the Size of Adenoid and its Related Obstructive Symptoms in Children with Adenoid Hypertrophy.

[摘要] Background::Adenoidhypertrophyisassociatedwithhighmorbidityrateinchildren.Althoughsurgicaltreatmentisindicatedinseverecases,however,thereareevidencesthatsomemedicalinterventionsareeffectiveinimprovement.Thisstudywasconductedtoevaluatetheeffectivenessofbeclomethasonenasalsprayonreductionofairwayobstructionduetoadenoidhypertrophy.Methods::Inaclinicaltrialstudy31childrenbetweentheagesof3-13yearssufferingfromexcessiveadenoidhypertrophywereadministeredbeclomethasonenasalspray(2puffseach12hr)fordurationof8-week.Allsubjectswereevaluatedforadenoidsizeandgradeofairwayobstructionbeforeandaftertheinterventionbylateralneckradiography.Aquestionnairewasfilledinbysubjects’parentstoassessobstructivesymptomsbeforeandaftertheintervention.Results::Radiographicfindingsrevealedthataftertreatmentadenoidsizewassignificantlylessthanitssizebeforetreatmentandairwaydiameterwassignificantlymorethanbeforetreatment.Alsofindingshowedthatsevereandmoderateformsofnasalobstructivefindingsafterinterventionweresignificantlylessfrequentthanbeforeit.Conclusion::Accordingtoourresearch,topicalnasalbeclomethasonecanleadtodecreasethesizeoftheadenoidandtheseverityofupperairwayobstructivesignsandsymptoms,aswellaseliminatingthedailysomnolenceofchildrenwithadenoidhypertrophy.

[学科分类] 基础医学

[关键词] Adenoid hypertrophy;Beclomethasone;Nasal spray;Airway obstruction