Effect of Measles Virus Antibodies from Breast Milk of Nursing Mothers on Seroconversion of Children After Measles Vaccination

[摘要] Theeffectsofmeaslesvirus(MV)antibodies(abs)intheseraandbreastmilkofnursingandlactatingmothersonsericonversiontomeaslesvaccinationwasstudied.ThreehundredandnintysixsampleswerecollectedeachfromseraandbreastmilkofnursingmothersandcorrespondingnumberoffingerprickprevaccinationserasamplesonfilterpaperfromtheirchildrenweretestedforMVabs.Eighty(20.2%)mothershadmeasleshaemagglutinationinhibition(HI)absintheirseraand88(27.2%)hadMVHIabsintheirbreastmilk.Eight(2.0%)ofthechildrenwhohadprevaccinationMVabsintheirserawereallfromMVabnegativemothers.Forty-four(37.0%)whocamebackforpostvaccinationseraseroconvertedwhile76(63.3%)gavealowseroconversionrateof37.0%.ResultsshowedthatMVabsineitherseraorbreastmilkofmothersdidnotinterferwithMVvaccinationintheirchildren.Thelowseroconversionrateobtainedwasduetolowvaccinepotencywithtitersrangingbetween(log10-1.0–log10-2.5)TCID/perdose.Thiswasbesideothernon-specificantiviralsubstancesexhibitedvirusneutralizingactivity.

[学科分类] 基础医学

[关键词] Measles;Antibodies;Seroconversion;Vaccination