Relationship of Conjunctival and Corneal Calcification with Secondary Hyperparathyroidism in Hemodialysis Patient

[摘要] HyperphosphatemiaistheconsequentofEnd-Stage-renalfailure.InadequatecontrolofserumphosphorusresultsinelevatedCa×Pproductandresultantsofttissuedepositionconsistofconjunctivalandcornealcalcification.Inthisstudyweevaluatedtherelationshipofconjunctivalandcornealcalcificationwithsecondaryhyperparathyroidisminhemodialysispatients.Thisisadescriptive–analyticstudywasdoneon24hemodialysispatients.Wemeasuredserumcalcium,phosphorus,alkalinephosphatase,iPTHandconjunctivalandcornealcalcificationbyusingslip–lampmicroscopeaccordingtoamodificationofporterscriteria.Totalpatientswere24.Thedurationofhemodialysiswere30.7±21.7months.Theresultsofbiochemicalvalueswere:Ca:9.1±0.8mg/dl,P:6.5±2.2mg/dl,ipTH:488±326pg/ml,Ca×P:51.5±16.6Themeanofconjunctivalandcornealcalcificationscorewas7.1±4.Therewereapositivecorrelationbetweenconjunctivalandcornealcalcificationwithdurationofhemodialysis(p=0.033,r=0.436),Ca×Pproduct(p=0.007,r=0.538).P(p=0.006,r=548)andipTH(p=0.028,r=0.449).Therewerenotanycorrelationbetweenconjunctivalandcornealcalcificationwithagesofthepatients,serumcalciumandalkalinphosphatase.Positivecorrelationofserumphosphorus,Ca×PproductandiPTHwithconjunctivalandcornealcalcificationandnosignificantcorrelationofcornealandconjunctivalcalcificationwithserumcalciummeansthatthereisacentralroleforphosphorusincalcium-phosphorusdepositioninsofttissueslikecorneaandconjunctivae,needstofurtherattentiontophosphoruscontrolinhemodialysispatients.

[学科分类] 基础医学

[关键词] Conjunctival and Corneal Calcification;Secondary Hyperparathyroidism in Hemodialysis.