Biliary Alkaline Phosphatase Isoenzyme in Biliary Obstruction.

[摘要] Alkalinephosphatase(ALP;EC3.1.3.1)ismainlyderivedfromtheliver,bonesandinlesseramountsfromintestines,placenta,kidneysandleukocytes.Araisedlevelofalkalinephosphataseinthebloodfrequentlyindicatesavarietyofdiseases.TheexaminationoftheALPisoenzymecanbeperformedbyelectrophoresis.Thisexaminationcanbehelpfulindiseaseclassificationofthosecaseswithhyperalkalinephosphatasemia.OfseveralALPisoenzymes,biliaryALPisoenzymeismentionedforitsclinicalusefulnessindetectionofbiliaryobstruction.Here,theauthorsperformedastudytoinvestigatetheclinicalusefulnessofbiliaryalkalinephosphataseisoenzymeinbiliaryobstruction.Ofinterest,thereisnosignificantdifferenceofserumALPlevelbetweenmalignantandbenignbiliaryobstructiongroup.Butthereisasignificantdifferenceofserumbiliary-ALPisoenzymebetweenmalignant(range28U/L–365U/l)andbenignbiliaryobstruction(range20–140U/L).Nevertheless,theaveragebiliary-ALPlevelofthecholangiocarcinomacases(range105–365U/L)issignificanthigherthantheothermalignantbiliaryobstructioncases(range28–50U/L).Accordingtoourstudy,thebiliary-ALPisoenzymedeterminationcanbeuseasamarkerformalignantbiliaryobstruction.

[学科分类] 基础医学

[关键词] Biliary;alkaline Phosphatase;Isoenzyme;Obstruction