Therapeutic and Adverse Effects of Glucantime Used for Treatment of Cutaneous Leishmaniasis.

[摘要] Introduction:CutaneousleishmaniasisisendemicinIran.Fasaregion(SouthernwestofIran)isoneofthehotspots.Themostpopulardrugfortreatmentofcutaneousleishmaniasisisglucantime.Aim:TostudythetherapeuticandadverseeffectsofGlucantimeincutaneousleishmaniasispatientsandalsocomparingtheintramuscularandintralesionaladministrationroutes.MaterialsandMethods:Allnewcutaneousleishmaniasiscases(880)thatwerediagnosedwithintwoyearsofstudywereruledin.Intralesionalinjectionwasusedforsolitarynonfacialwounds,formaximumof10doses,injectedeveryotherday.Formultiplelesionsorfaciallesions,intramuscularinjectionwasperformed,indailymannerformaximumofthree10dayperiods,apartby10daysofdrugfreeintervals.InjectionsweredoneaccordingtoWHOguidelines.Results:Therecoveryratewas84.03%and75.98%inintramuscularandintralesionalinjectiongroups,respectively.Themostcommonsideeffectwasskinhypersensitivityandurticaria,whichwasmoreseeninthosewithintralesionalinjection(10.92%incomparisonwith2.59%inIMgroup).Nocardiacorrenalcomplicationwasobserved.Conclusion:CompleterecoveryishigherinintramuscularinjectioncomparedtointralesionalinjectionofGlucantimeforcutaneousleishmaniasis.Sideeffectsarealsolessseenintheintramuscularinjection.

[学科分类] 基础医学

[关键词] Cutaneous leishmaniasis;Glucantime.