Lipoprotein (a) level in acute myocardial infarction: comparison with healthy subjects

[摘要] Increasedlipoprotein(a)[LP(a)]concentrationwasreportedtobeanindependentriskfactorforcoronaryheartdisease(CHD).ThisstudywasperformedtodeterminethelevelofLp(a)andotherlipidsinpatientswithacutemyocardialinfarctionandcomparingthemwithmatchedhealthysubjects.Westudiedatotalof43caseswhoadmittedtocoronarycareunit(CCU)foracutemyocardialinfarction(MI)andalso43healthysubjects.DatacollectioncomprisedLp(a),totalcholesterol,LDL-cholestrol(LDL-C),HDL-cholestrol(HDL-C)levelandmedicalhistory.ThemeanLp(a)levelinacuteMIcaseswas49.18mg/dl,andinthecontrolgroupwas37.95mg/dl.Therewassignificantdifferencebetweentwogroups(p=0.018).ThemeantotalcholesterolLDL-CandHDL_C,levelinacuteMIcaseswere183.9,106.5and58.12mg/dlrespectivelyandincontrolcaseswere227,145.8and51mg/dlrespectively.ThemeanlevelofLp(a)inwomen(caseamp;control)was50mg/dlthatwashigherthanmen(37.1mg/dl).AlsoLp(a)wasindependentofotherlipids.AsoneofthefirststudiesaboutLp(a)inAcuteMIpatients,thisstudyshowsthataverageLp(a)levelinpatientswithacuteMIishigherthancontrolpatients.Anotherinterestingfindingisthatlevelinwomenishigherthanmen.Werecommendcomplementaryepidemiologicstudytoevaluatethisfinding.

[学科分类] 基础医学