Value of Core Needle Biopsy as the First Diagnostic Procedure in the Palpable Breast Masses.

[摘要] Background:Breastcoreneedlebiopsy(CNB)providesenoughtissueforhistopathologicdiagnosisandisconsideredareliablemethodforestablishingpreoperativetissuediagnosis.ThepurposeofthisstudyistoevaluateCNBasthefirstdiagnosticstepinsteadofexcisionalbiopsyinpalpablebreastmasses.MaterialsandMethods:Inthisprospectivestudy,patientswithpalpablebreastmasswhounderwentCNBwereenrolled.Basedonpathologyreport,patientswithmalignantlesionsrevealedbyCNBwereimmediatelycandidateforsurgeryandthosewhohadbenignlesionswerefollowedupto3years.Results:112femaleswithpalpablebreastmasswereenrolledinthestudy.In103(91.9%)ofcasesfirstattemptCNBprovidedadequatesampletissue.CNBdetectedmalignantlesioninseventyeight(69.6%)patients.All(100%)malignantCNBreportswereconfirmedatsurgeryspecimenpathology.In34(30.4%)patientsCNBrevealedbenignlesion.Attheendof3yearsfollowupperiod,25(73%)ofthesepatientsunderwentopenbiopsyleadingtothedetectionof1(3%)malignanttumor.Overall,accordingtothegoldstandarddefinedaspositivesurgicalbiopsyorpositivefollow-up,sensitivityofCNBwascalculatedas98.7%(95%CI,94.1-100%)anditsaccuracywas99.1%(95%CI,97.4-100%).ThespecificityoftheCNBprocedurewas100%.Conclusion:ThesefindingssuggestthatthemalignancydetectionpowerprovidedbyCNBmaybeweighedequaltothatofopenbiopsy.Therefore,weproposeCNBasthefirstchoiceindiagnosticevaluationofpalpablebreastmassespeciallyforthoseinaccessiblesitesandinexperiencedhands.

[学科分类] 基础医学

[关键词] Breast mass;breast cancer;malignancy;biopsy;core needle biopsy