Magnesium Sulfate versus HCG (Human Chorionic Gonadotropin) in Suppression of Preterm Labor.

[摘要] Introduction:Pretermlaborisdefinedasdeliverybefore37completedweeksofpregnancy.Since10%oftotallaborsarepretermand70%ofinfants’mortalityisduetothisproblem,pretermlaborisanimportantprobleminobstetrics,midwiferyandpediatrics.Sothatdifferenttreatmentshavebeenemployedinordertosuppresspretermlaborfromseveralyearsago.Magnesiumsulfateisoftenusedasafirst-lineinsuppressingofpretermlabor,althoughitsmaternalandneonatalsideeffectsarecommon,inbestofconditionsonly24-48hoursdelaysoflabor,andrandomizedclinicaltrialstudieshaveshownthatinsuppressionofpretermlaboritisaseffectiveasplacebo.OntheotherhandbecauseofknownabilityofHumanChorionicGonadotropin(HCG)insuppressionofcontractionsinmusclesdetachedfromhumanmyometer(invitro),andsafetyofthisdruginpregnancy,wetakeadecisionthatcomparetheabilityofMagnesiumSulfatewithHCGinsuppressionofpretermlabor.MaterialsandMethods:Inthisclinicaltrialstudy,64caseswerechosenfrompregnantwomenbetweenthe24-34weeksofpregnancywhoweresufferingfrompretermcontractionsofuteruswithintactamnioticsacandcervicaldilatationoflessthan4cm.ThesewomenhadreferredtoobstetricwardofAli-Ebne-AbitalibHospital,Zahedan,Iranduringtheyearsof2004-6andrandomlyweredividedintotwoequalgroups(32casesineachgroup)Infirstgroupprimarily4gramsofMagnesiumSulfate(1gramperminute)infusedandthen2gramsperhourwascontinued.Whereas,insecondgroupHCGwasinjectedfirstly5000unitsintramuscularlyandtheninfused20unitsperminute.Treatmentsinbothgroupswerecontinuedto12hoursafteruterinecontractionsstoppage,duringthetreatmentstherapeuticeffectsaswellasmaternalconditionsandcomplainswererecordedinbothgroups.TheresultswereanalyzedbyChisquareandTtestwithSPSSsoftware,differentiationwasregardedassignificantifPvalue

[学科分类] 基础医学

[关键词] HCG;Magnesium Sulfate;Preterm labor.