Blood Rheology, Haemostatic Function and Peripheral Blood Flow in Diabetes Mellitus: A Study of the Effects of Improved Blood Glucose Control and Treatment With Biosynthetic Human Insulin

[摘要] The aims of the studies were to examine blood rheology, haemostatic factors and peripheral blood flow in diabetes mellitus in relation to treatment and the presence of vascular damage. First, studies of the specificity of positive pressure filtration of dilute erythrocyte suspensions as a measure of erythrocyte deformability were made. Second, the effects of improved blood glucose control (achieved by outpatient management) on whole blood viscosity, haemostatic factors, peripheral blood flow and peripheral nerve function was examined. Third, a double-blind crossover study of the effects of treatment with biosynthetic human insulin (BHI) and purified porcine insulin (PPI) on blood rheology, haemostatic factors and peripheral blood flow was carried out.

[发布机构] University:University of Glasgow

[关键词] Medicine, Physiology