Selective Manipulation of Tumour Cell Energy Metabolism

[摘要] Rapidly growing, glycolytic tumours which are poorly differentiated were shown to contain functional mitochondria capable of oxidative phosphorylation. Mitochondria were isolated and assessed for use in screening potential antimitochondrial agents in vitro. As this model proved to be unsuitable, a second model, intact cells were employed for screening purposes. The effect of antimitochondrial agents on the metabolism of cultured tumour cells was compared to that in freshly isolated rat hepatocytes.

[发布机构] University:University of Glasgow

[关键词] Medicine, Physiology, Cellular biology, Oncology