Verapamil and Polyunsaturated Fatty Acids As Resistance Modulators In Vitro

[摘要] The development of resistance is thought to be a major cause of treatment failure in cancer patients. Multidrug resistance is a form in which tumour cells develop cross-resistance to a range of natural products. This is commonly associated with increased expression of P- glycoprotein, which appears to act as a membrane efflux pump. The aims of the present studies were firstly to further characterise the mechanisms by which verapamil can sensitise resistant tumour cells to cytotoxic drugs, and secondly to investigate polyunsaturated fatty acids as an alternative means of sensitising drug resistant cell lines.

[发布机构] University:University of Glasgow

[关键词] Medicine, Pharmacology, Oncology