The Regulation of Adenylate Cyclase in Adipose Tissue From the Streptozotocin Diabetic Rat, the Obese Zucker Rat and the Diabetic Mouse

[摘要] In this study I have investigated alterations in the regulation and hormonal responsiveness of adipocyte adenylate cyclase occurring in animal models showing insulin-resistance. Three models have been investigated, the streptozotocin diabetic rat, which approximates as a model of juvenile onset diabetes in humans, genetically obese Zucker fatty rat, approximating a model of human obesity and the genetically obese diabetic mouse, which also approximates to a model of human obesity. My reason for undertaking such a study was because therapeutic benefits may come from a greater understanding of alterations in signal transduction systems of hormones controlling metabolism in insulin-resistant pathological states. These are seen in diabetes and in obesity where profound alterations in metabolism have been noted. An important underlying facet in determining these alterations in metabolism may be that defects have occurred in signal transduction systems of various hormones which regulate metabolic events. Any such changes occuring in signal transduction systems associated with the liver, skeletal muscle and adipose tissue are likely to give rise to serious metabolic disturbances.

[发布机构] University:University of Glasgow

[关键词] Biochemistry, Physiology