Studies on Equine Intestinal Permeability to 51Cr-EDTA

[摘要] The aim of the studies reported in this thesis was to evaluate the suitability of 51Chromium-labelled ethylenediaminetetraacetate (51Cr-EDTA) as a marker for the assessment of intestinal permeability in the horse. Initial studies were performed in apparently healthy ponies. The percentages of orally administered 51Cr-EDTA measured in urine were found to be consistent and not significantly affected by alterations on intestinal motility following premedication with atropine or bethanecol. Absorption of a proportion of 51Cr-EDTA from the large intestine was confirmed following intracaecal administration of test doses in two animals with permanent caecal fistulation. The 51Cr-EDTA test was used to investigate alterations in intestinal permeability in ponies following induction of enteropathy by experimental cyathostome infection and by prolonged phenylbutazone administration. Alterations of intestinal permeability were detected in cyathostome-infected animals but similar changes were not seen following phenylbutazone administration. To some extent these results confirm the reliability of the test since parasitic typhlitis/colitis was detected at post-mortem examination in two animals whereas there were no clinical or laboratory evidence of phenylbutazone toxicity in the animals studied. Intestinal permeability was investigated by use of the 51Cr-EDTA test on three clinical cases with naturally-occurring chronic enteropathy and found to be increased in one horse.

[发布机构] University:University of Glasgow

[关键词] Veterinary science