The Role of 1,25 Dihydroxyvitamin D3 and Other Calciotrophic Hormones as Immunoregulatory Agents

[摘要] Over the years it has been well documented that there is a connection between the immune system and the endocrine system certainly as far as vitamin D was concerned. The major breakthrough came when vitamin D receptors were demonstrated on various cells whose principal task was to mount an immune response. 1,25 Dihydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of vitamin D, was demonstrated to inhibit cell proliferation and to inhibit interleukin-2 (IL-2) activity (Tsoukas, 1984). In this thesis the roles of 1,25(OH)2D3 and other calciotrophic hormones as immunoregulatory agents are addressed.

[发布机构] University:University of Glasgow

[关键词] Medicine, Immunology