Regulation of the aldosterone synthase gene-role in human hypertension and adrenal corticosteroid production

[摘要] Despite many advances in technology and significant levels of funding, the genetic factors that regulate blood pressure in the population remain unclear. The public health implications of this lack of knowledge are conspicuous and a better understanding of the mechanisms behind hypertension would lead to better management of this important risk factor. The myriad of physiological systems involved in maintaining blood pressure can be variably dysregulated in patients with hypertension. Therefore, taking more account of hypertension as a heterogeneous condition may be a useful approach. Given the lack of success in dissecting the genetic factors to date, it seems reasonable to refocus attention on more carefully phenotyped groups of subjects, with the aim of identifying mechanisms specific to them.

[发布机构] University:University of Glasgow;Department:Institute of Cardiovascular and Medical Sciences

[关键词] R Medicine (General)