Effects of collagen and of aspirin on the concentration of guanosine 3′:5′-cyclic monophosphate in human blood platelets: measurement by a prelabelling technique (Short Communication)

[摘要]

A method is described for isolating cyclic [³H]GMP from platelets preincubated with [³H]guanine. Collagen increased and aspirin decreased the cyclic [³H]GMP concentration in platelets. The results are consistent with a role for cyclic GMP in the platelet release reaction.